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心肾代谢综合征（CKM）涉及代谢、肾脏和心血管多系统病变，多器官损伤相互叠加、形成恶性循环，是当前慢病一体化管理的核心难点。2026年8月28日至31日，欧洲心脏病学会年会（ESC）将在德国慕尼黑举行！大会设置了多场CKM专属论坛、摘要汇报与壁报交流，先来看看都有哪些精彩内容吧~


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研讨会

Innovations in lipid lowering and cardiometabolic disease
降脂治疗与心代谢疾病领域创新进展

北京时间：2026-08-28 14:15-15:45

地点：Vienna(ICM)

内容简介：

本场聚焦新一代降脂药物与CKM靶向疗法前沿突破，系统梳理心代谢疾病药理学革新方向，并围绕针对重度高甘油三酯血症的反义核酸药物olezarsen、新型每月一次注射制剂Ticalicibart与2型糖尿病药物HTD1801等创新药物临床试验数据展开深度解读。

具体讲题：

State-of-the-art lecture on next generation cardiometabolic pharmacology: from lipids to RNA therapeutics

前沿专题讲座：新一代心代谢药理学——从脂质调控到RNA疗法

Long-term efficacy and safety of olezarsen in patients with severe hypertriglyceridemia

Olezarsen用于重度高甘油三酯血症患者的长期疗效与安全性

HTD1801 as a multisystem cardio-kidney-metabolic therapy in type 2 diabetes: phase 3 SYMPHONY Trials demonstrate early CKM risk modification

HTD1801作为2型糖尿病多系统心肾代谢药物：Ⅲ期SYMPHONY研究证实其可早期干预心肾代谢（CKM）风险

Ticalicibart monthly as add-on therapy to statins for nonfamilial hypercholesterolemia: the randomized, phase 3 TIMER trial

每月一次Ticalicibart联合他汀治疗非家族性高胆固醇血症：随机Ⅲ期TIMER临床试验

Cardiometabolic Disease: A New or Old Syndrome?
心代谢疾病：新综合征还是旧相识？

北京时间：2026-08-30 22:15-23:15

地点：Chisinau - Hall B1

内容简介：

与德国心脏病学会合作举办，提升对心代谢疾病的认知，梳理心肾代谢综合征的病理生理基础，审视GLP-1激动剂是否已成为所有心血管患者的新标准，并阐明心代谢疾病与HFpEF是否为同一疾病，探讨诊断与治疗挑战。

具体讲题：

心肾代谢综合征：理解与管理这一挑战

GLP-1激动剂：所有心血管患者的新标准？

射血分数保留心衰与心代谢综合征：同一疾病？

Cardio-renal-metabolic syndrome: the triple threat
心肾代谢综合征：三重健康威胁

北京时间：2026-08-30 14:15-15:45

地点：Athens(ICM)

内容简介：

聚焦于心肾代谢综合征的前沿进展，涵盖基于大样本登记队列和超大规模人群数据库的多项真实世界研究，探讨CKM相关心血管风险的隐匿特征与人群差异、糖尿病临界人群的心血管隐患、2型糖尿病心血管风险的性别分层，以及GLP1受体激动剂在非糖尿病动脉粥样硬化心血管病中的风险导向用药策略。

具体讲题：

State-of-the-art lecture on cardio-renal-metabolic syndrome

心肾代谢综合征前沿专题讲座

Cardiovascular risk emerges below the diagnostic threshold for diabetes: insights from the Western Denmark Heart Registry

糖尿病诊断阈值之下已存在心血管发病风险：丹麦西部心脏登记数据库研究启示

Association of clonal hematopoiesis with cardiovascular-kidney-metabolic syndrome in 434,000 individuals

43.4万人群中克隆性造血与心肾代谢综合征相关性的研究

Sex differences in excess risk of cardiovascular disease and mortality among patients with type 2 diabetes: a matched register-based cohort study

2型糖尿病患者心血管疾病及超额风险与死亡率的性别差异：一项基于登记数据库的匹配

Risk-based thresholds enable efficient allocation of GLP-1 receptor agonists in atherosclerotic cardiovascular disease without diabetes

基于风险分层阈值可实现GLP-1受体激动剂在非糖尿病动脉粥样硬化性心血管病患者中的精准使用

Optimising outcomes in cardio-renal-metabolic patients
优化心肾代谢疾病患者远期临床结局

北京时间：2026-08-30 23:30  次日 00:30 

地点：Athens(ICM)

内容简介：

围绕心肾代谢共病诊疗落地展开交流，内容涵盖心肾代谢疾病多系统损伤的内在病理生理机制、糖肾合并患者心血管药物落地实操方案、共病患者规范化诊疗路径，以及国家级慢病防控策略以改善长期预后。

具体讲题：

Pathophysiological basis of cardiorenal metabolic disease: why and how are they linked?

心肾代谢疾病的病理生理基础：多系统损伤的内在关联机制

Rapid implementation of cardiovascular risk reducing therapies in chronic kidney disease and type 2 diabetes - practical guidance

慢性肾脏病合并2型糖尿病患者心血管风险降低疗法的快速落地实施——临床实操指南

Cardio-renal-metabolic patients: where and how to manage treatment

心肾代谢疾病患者：治疗管理的切入点与实施策略

Optimising outcomes in metabolic cardiovascular disease: national approaches for prevention

代谢性心血管疾病结局优化：国家级防控策略

摘要报告

Cardiorenal Metabolic Disease Mechanisms and Treatment

心肾代谢疾病机制与治疗

北京时间：2026-08-30 16:45-17:45

地点：Science Box 2（Research Gateway-Hall A1）

1. 腹型肥胖相比全身性肥胖更早、更高地增加心肾代谢综合征风险：NHANES横断面研究

Abdominal obesity leads to earlier and higher CKM syndrome risk than general obesity: a cross-sectional NHANES study

讲者：Qian-Hui Tai（西安交通大学第一附属医院）

2. 墨西哥成人脂肪蓄积与糖尿病：大型前瞻性研究的观察性及孟德尔随机化分析证据

Adiposity and diabetes in Mexican adults: evidence from observational and mendelian randomization analyses of a large prospective study

讲者：Louisa G Friedrichs（University of Oxford, Oxford, United Kingdom）

3. 2型糖尿病SGLT2i对比GLP-1药物的心肾代谢风险分层与心肾结局：全球联合网络研究

Cardiovascular-kidney-metabolic risk stratification and cardiorenal outcomes with SGLT2 inhibitors versus GLP-1 receptor agonists in type 2 diabetes: a global federated network study

讲者：Chen Wang（United Kingdom）

4. 儿童至成年长期BMI负荷、波动与中年心肾代谢综合征：36年随访队列研究

Long-term BMI burden, its variability from childhood to adulthood and cardiovascular-kidney-metabolic syndrome in midlife: a 36-year cohort study

讲者：Guilin Hu（西安交通大学第一附属医院）

5. 基于基因分型内型的蛋白质组图谱分析揭示肥胖分子异质性

Proteomic profiling of genetically defined endotypes reveals molecular heterogeneity of obesity

讲者：Devesh Malik（United States of America）

6. GLP-1受体激动剂对非糖尿病超重人群的心血管保护作用：大型结局试验Meta分析

Cardiovascular protective effects of GLP-1 receptor agonists in non-diabetic overweight patients: a meta-analysis of large-scale outcomes trials

讲者：Umid Huseynzada（Samsun, Turkiye）

电子壁报

Predicting cardio-renal-metabolic disease (1)
心肾代谢疾病预测（1）

北京时间：2026-08-29 23:15-次日 00:00  

地点：Station 7(Research Gateway-Hall A1)

A risk calculator for cognitive decline in heart failure: a dual-stage machine learning analysis of the WARCEF trial

心力衰竭患者认知功能减退风险预测模型：基于WARCEF试验数据的双阶段机器学习分析

Machine learning-based all-cause mortality risk assessment integrating novel biomarkers in patients with suspected or known coronary artery disease: the AI-ANOX-EXCEED-J Study

整合新型生物标志物的机器学习模型评估可疑/确诊冠心病患者全因死亡风险：AI-ANOX-EXCEED-J研究

Serum Let-7b and AKT3 predict cardiovascular death in type 2 diabetes: insights from miRNA profiling and target prediction

血清Let-7b与AKT3可预测2型糖尿病患者心血管死亡：微小RNA谱及靶基因预测研究

Combined assessment of stress hyperglycemia ratio and hemoglobin glycation index to predict mortality after coronary revascularisation: a machine learning study

应激高血糖比值联合糖化血红蛋白指数预测冠脉血运重建术后死亡风险：机器学习研究

Relationship between atherosclerotic burden and subclinical cardiac dysfunction in Type 2 Diabetes

2型糖尿病患者动脉粥样硬化负荷与亚临床心功能障碍的相关性

Fourteen-year risk of MACE stratified by NT-proBNP and inflammatory biomarkers in type 2 diabetes

基于NT-proBNP及炎症生物标志物分层的2型糖尿病患者14年主要不良心血管事件风险

Integrating genetic, clinical, and behavioural factors may improve the prediction of type 2 diabetes

整合遗传、临床及行为学因素可提升2型糖尿病发病预测效能

Interpretable machine learning-derived risk score for significant coronary artery calcification in a real-world clinical cohort

基于可解释机器学习构建真实世界人群显著冠脉钙化风险评分

Predicting cardio-renal-metabolic disease (2)
心肾代谢疾病预测（2）

北京时间：2026-08-30 16:15-17:00 

地点：Station 7(Research Gateway-Hall A1)

Coronary inflammation predicts cardiovascular risk in the absence of standard modifiable risk factors (SMuRFs): the ORFAN study

无标准可变危险因素(SMuRFs)人群中，冠脉炎症可预测心血管风险：ORFAN研究

Global cardiovascular risk prediction model in the Cuban population

适用于古巴人群的通用心血管风险预测模型

Sex specific serum uric acid is associated with complex coronary artery disease and cardiovascular outcome following percutaneous coronary intervention-a single center registry

性别特异性血尿酸水平与复杂冠心病及经皮冠脉介入术后心血管终点事件相关：单中心登记研究

Elevated levels of the incretin hormone PYY are associated with cardiovascular events

肠促胰素PYY升高与心血管不良事件存在相关性

The prognostic value of ECG parameters for 20-year cardiovascular risk and incremental improvement of SCORE2-based prediction modelling: the ATTICA cohort study (2002–2022)

心电图参数对20年心血管风险的预测价值及其对SCORE2预测模型的增量效能：ATTICA 队列研究（2002–2022）

Empowering nursing students with knowledge and confidence in cardiovascular risk awareness and prevention education: ASMOSUS a digital educational resource.

数字化教学工具ASMOSUS提升护理专业学生心血管风险认知与预防宣教能力

Life's Essential 8 and SCORE2 for cardiovascular risk prediction in a middle-aged general population: the Akershus Cardiac Examination 1950 Study

心血管健康八大指标联合SCORE2模型预测普通中年人群心血管风险：Akershus心脏筛查1950研究

Lipoprotein (a) and hs-CRP interplay as a driver of polyvascular atherosclerosis and cardiovascular events

脂蛋白a与超敏C反应蛋白协同驱动多支血管动脉粥样硬化及心血管不良事件

Predicting cardio-renal-metabolic disease (3)
心肾代谢疾病预测（3）

北京时间：2026-08-31 20:15-21:00

地点：Station 7 (Research Gateway-Hall A1)

Interatrial septal thickness and risk of incident atrial fibrillation

房间隔厚度与新发房颤发病风险的关联

Long-term risk of cardiac arrest according to a cardiovascular polygenic risk score in a population-based cohort

基于心血管多基因风险评分的人群长期心脏骤停发病风险研究

Sex-specific distribution and prognostic significance of p-wave duration in a population-based cohort

人群队列中P波时限的性别分布特征及预后价值

The TG-HDL-C ratio is associated with incident MACE in normoglycemic individuals without diabetes: findings from a Swedish population-based cohort

甘油三酯/高密度脂蛋白胆固醇比值与无糖代谢异常人群新发主要不良心血管事件相关：瑞典人群队列研究结果

Comparing left atrial volume indexation methods for predicting major adverse cardiovascular events and atrial fibrillation: Data from the Akershus Cardiac Examination 1950 Study

不同左房容积校正方式预测主要不良心血管事件与房颤效能对比：阿克什胡斯心脏队列1950研究数据

Joint association of early vascular aging and frailty with major adverse cardiovascular events: a Chinese community-based cohort study

早期血管衰老联合衰弱状态与主要不良心血管事件的协同关联：中国社区队列研究

One-year worsening of cardio-ankle vascular index predicts cardiovascular events in adults younger than 65 years

心踝血管指数1年内进展恶化可预测65岁以下成人心血管不良事件

Cardiac structure, function, and symptoms in cardiometabolic and systemic disease
心代谢及全身性疾病中的心脏结构、心功能与临床症状

北京时间：2026-08-30 16:15-17:00

地点：Station 9 (Research Gateway-Hall A1)

Fibrosis-4 (FIB-4) score is associated with early diastolic dysfunction in metabolic dysfunction-associated steatotic liver disease (MASLD)

FIB‑4 评分与代谢功能障碍相关脂肪性肝病（MASLD）患者早期舒张功能障碍相关

Associations between cardiac biomarkers and cardiac structure and function in patients with psoriasis

银屑病患者心脏生物标志物与心脏结构、心功能的相关性

Cardiovascular-kidney-metabolic (CKM) syndrome stage is associated with impaired cardiac structure/function and increased symptom burden in patients with MASLD

心肾代谢（CKM）综合征分期与代谢功能障碍相关脂肪性肝病患者心脏结构/功能损伤及症状负荷加重相关

Prevalence of cardiac dysfunction and symptoms in long COVID

长新冠患者心功能异常及相关症状的患病情况

Global myocardial performance and long-term mortality after TAVI: prognostic value of the TEI index

经导管主动脉瓣置换术后整体心肌功能与远期死亡率：TEI心肌综合指数的预后评估价值

The cystatin c-to-creatinine eGFR ratio and subclinical cardiac structure and function in a population-based cohort

基于人群队列研究：胱抑素C/肌酐估算肾小球滤过率比值与亚临床心脏结构及心功能的关联

The remodeling paradox in ischemic HFrEF: dissociation between left ventricular cavity reduction and functional recovery according to ischemic phenotype

缺血性射血分数降低心衰的重构悖论：不同缺血表型下左室腔缩小与心功能恢复不同步现象

Lung water at rest: B-lines on ultrasound predict mortality in chronic coronary syndromes

静息肺水：超声B线可预测慢性冠脉综合征患者死亡风险

结语

ESC 2026慕尼黑之约即将隆重启幕，让我们共同期待这场心血管代谢领域的学术盛会！后续，小编将持续带来大会现场的一手速递与深度解读，敬请关注。